abstract：:Pharmacological and genetic rodent models of schizophrenia play an important role in the drug discovery pipeline, but quantifying the molecular similarity of such models with the underlying human pathophysiology has proved difficult. We developed a novel systems biology methodology for the direct comparison of anterio...

journal_title：Schizophrenia research

authors： Cox DA,Gottschalk MG,Wesseling H,Ernst A,Cooper JD,Bahn S

更新日期：2016-11-01 00:00:00

abstract：:Reduced glutamatergic activity and energy metabolism in the dorsolateral prefrontal cortex (DLPFC) have been described in schizophrenia. Glycogenolysis in astrocytes is responsible for providing neurons with lactate as a transient energy supply helping to couple glutamatergic neurotransmission and glucose utilization ...

journal_title：Schizophrenia research

authors： Pinacho R,Vila E,Prades R,Tarragó T,Castro E,Ferrer I,Ramos B

更新日期：2016-11-01 00:00:00

abstract：:Schizophrenia constitutes a complex disease. Negative and cognitive symptoms are enduring and debilitating components of the disorder, highly associated to disability and burden. Disrupted neurotransmission circuits in dorsolateral prefrontal cortex (DLPFC) have been related to these symptoms. To identify candidates a...

journal_title：Schizophrenia research

authors： Pinacho R,Villalmanzo N,Meana JJ,Ferrer I,Berengueras A,Haro JM,Villén J,Ramos B

更新日期：2016-11-01 00:00:00

abstract：:Schizophrenia is a multifactorial disease in both clinical and molecular terms. Thus, depicting the molecular aspects of the disease will contribute to the understanding of its biochemical mechanisms and consequently may lead to the development of new treatment strategies. The protein phosphorylation/dephosphorylation...

journal_title：Schizophrenia research

authors： Saia-Cereda VM,Cassoli JS,Schmitt A,Falkai P,Martins-de-Souza D

更新日期：2016-11-01 00:00:00

abstract：:Converging lines of evidence implicate structural and functional abnormalities in the cerebellum in schizophrenia (SCZ). The cerebellar vermis is of particular interest given its association with clinical symptoms and cognitive deficits in SCZ and its known connections with cortical regions such as the prefrontal cort...

journal_title：Schizophrenia research

authors： Womer FY,Tang Y,Harms MP,Bai C,Chang M,Jiang X,Wei S,Wang F,Barch DM

更新日期：2016-10-01 00:00:00

abstract：:Schizophrenia is characterized by increased mortality for which suicidality is the decisive factor. An analysis of cortical thickness and folding to further elucidate neuroanatomical correlates of suicidality in schizophrenia has not yet been performed. We searched for relevant brain regions with such differences betw...

journal_title：Schizophrenia research

authors： Besteher B,Wagner G,Koch K,Schachtzabel C,Reichenbach JR,Schlösser R,Sauer H,Schultz CC

更新日期：2016-10-01 00:00:00

abstract：:The author previously proposed that schizophrenia has similar cytokine expression compared to melanoma, a neural crest cell tumor. One possible tumor model of schizophrenia includes anti-NMDA receptor encephalitis, a paraneoplastic syndrome. While examining the possible relationship of neural crest cell tumors to schi...

journal_title：Schizophrenia research

authors： Brown JS Jr

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Executive dysfunction is a common feature of schizophrenia and bipolar disorder (BP). While deficits in social cognitive abilities, including theory of mind (ToM), have been suggested to be specific to schizophrenia, available evidence suggests that there is also a significant overlap in social cognitive perf...

journal_title：Schizophrenia research

authors： Bora E,Veznedaroğlu B,Vahip S

更新日期：2016-10-01 00:00:00

abstract：:Elevated serum levels of Interleukin-3 (IL-3), a major component of the cytokines, have been observed in chronic and medicated patients with schizophrenia, but this elevation may reflect either or both medication and illness chronicity effects. Thus, we compared serum IL-3 levels in first-episode drug-naive (FEDN) to ...

journal_title：Schizophrenia research

authors： Fu YY,Zhang T,Xiu MH,Tang W,Han M,Yun LT,Chen DC,Chen S,Tan SP,Soares JC,Tang WJ,Zhang XY

更新日期：2016-10-01 00:00:00

abstract：:Schizoaffective disorder is a common diagnosis in clinical practice but its nosological status has been subject to debate ever since it was conceptualized. Although it is key that diagnostic reliability is sufficient, schizoaffective disorder has been reported to have low interrater reliability. Evidence based on syst...

journal_title：Schizophrenia research

authors： Santelmann H,Franklin J,Bußhoff J,Baethge C

更新日期：2016-10-01 00:00:00

abstract：:Autoimmunity, gastrointestinal (GI) disorders and schizophrenia have been associated with one another for a long time. This paper reviews these connections and provides a context by which multiple risk factors for schizophrenia may be related. Epidemiological studies strongly link schizophrenia with autoimmune disorde...

journal_title：Schizophrenia research

authors： Severance EG,Yolken RH,Eaton WW

更新日期：2016-09-01 00:00:00

abstract：:Astrocytes regulate multiple processes in the brain ranging from trophic support of developing neurons to modulation of synaptic neurotransmission and neuroinflammation in adulthood. It is, therefore, understandable that pathogenesis and pathophysiology of major psychiatric disorders involve astrocyte dysfunctions. Un...

journal_title：Schizophrenia research

authors： Xia M,Abazyan S,Jouroukhin Y,Pletnikov M

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Young adults with early phase schizophrenia often report a past or current pattern of illicit substance use and/or alcohol misuse. Still, little is known about the cumulative and separate effects of each stressor on white matter tissue, at this vulnerable period of brain development. METHODS:Participants inv...

journal_title：Schizophrenia research

authors： Bernier D,Bartha R,McAllindon D,Hanstock CC,Marchand Y,Dillen KNH,Gallant M,Good KP,Tibbo PG

更新日期：2016-08-01 00:00:00

abstract：:Autism and schizophrenia share multiple phenotypic and genotypic markers, and there is ongoing debate regarding the relationship of these two disorders. To examine whether cortical dynamics are similar across these disorders, we directly compared fMRI responses to visual, somatosensory and auditory stimuli in adults w...

journal_title：Schizophrenia research

authors： Haigh SM,Gupta A,Barb SM,Glass SAF,Minshew NJ,Dinstein I,Heeger DJ,Eack SM,Behrmann M

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Altered motor behavior has consistently been reported in medication-naive adult patients with schizophrenia and first episode psychosis and adults at clinical high risk for psychosis (CHR). This study is the first to evaluate the prevalence of abnormal involuntary movements in a community sample of children ...

journal_title：Schizophrenia research

authors： Kindler J,Schultze-Lutter F,Michel C,Martz-Irngartinger A,Linder C,Schmidt SJ,Stegmayer K,Schimmelmann BG,Walther S

更新日期：2016-07-01 00:00:00

abstract：:Schizophrenia (SZ) is associated with broad burden. The clinical manifestations of SZ are related to pathophysiological alterations similar to what is seen in normal aging. Our aim was to evaluate the differences in telomere length (TL), a biomarker of cellular aging, in subjects with SZ (n=36), unaffected siblings (S...

journal_title：Schizophrenia research

authors： Czepielewski LS,Massuda R,Panizzutti B,da Rosa ED,de Lucena D,Macêdo D,Grun LK,Barbé-Tuana FM,Gama CS

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:There is increased interest in the impact of new long-acting treatments on health-related quality of life (HRQoL) in patients with schizophrenia. The aim of this study was to evaluate the impact of treatment with subcutaneous injections of RBP-7000, a new sustained-release formulation of risperidone, compare...

journal_title：Schizophrenia research

authors： Isitt JJ,Nadipelli VR,Kouassi A,Fava M,Heidbreder C

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:The use of dopaminergic antagonist antipsychotics is associated with hyperprolactinemia, but some studies have found increased prolactin concentrations in antipsychotic-naive patients with schizophrenia and related disorders. We conducted a systematic review and meta-analysis of studies of prolactin in antips...

journal_title：Schizophrenia research

authors： González-Blanco L,Greenhalgh AMD,Garcia-Rizo C,Fernandez-Egea E,Miller BJ,Kirkpatrick B

更新日期：2016-07-01 00:00:00

abstract：:Second-generation antipsychotics have demonstrated efficacy for patients with schizophrenia but are associated with wide-ranging side effects. Brexpiprazole, a serotonin-dopamine activity modulator, has demonstrated efficacy in adult patients with schizophrenia. This paper provides an overview of the safety and tolera...

journal_title：Schizophrenia research

authors： Kane JM,Skuban A,Hobart M,Ouyang J,Weiller E,Weiss C,Correll CU

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:Aripiprazole has been associated with a low prevalence of metabolic side effects as compared to other second generation antipsychotic (SGA) medications mostly in patients with long standing illness. The purpose of the present study was to assess specifically the effectiveness and safety of aripiprazole as ...

journal_title：Schizophrenia research

authors： Malla A,Mustafa S,Rho A,Abadi S,Lepage M,Joober R

更新日期：2016-07-01 00:00:00

abstract：:Schizophrenia is associated with structural brain abnormalities that are likely to be present before disease onset. It remains unclear to what extent these represent general vulnerability indicators or are associated with the developing clinical state itself. It also remains unclear whether such state or trait alterat...

journal_title：Schizophrenia research

authors： Bois C,Levita L,Ripp I,Owens DCG,Johnstone EC,Whalley HC,Lawrie SM

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Internalized stigma can lead to pervasive negative effects among people with severe mental illness (SMI). Although prevalence of internalized stigma is high, there is a dearth of interventions and meanwhile a lack of evidence as to their effectiveness. This study aims at unraveling the existence of different ...

journal_title：Schizophrenia research

authors： Tsang HW,Ching SC,Tang KH,Lam HT,Law PY,Wan CN

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Functional remission (FR) is an intermediate and necessary step toward recovery, but is understudied in first-episode psychosis (FEP). We aimed to examine the rate and predictors of FR in FEP patients in the context of a randomized-controlled trial (RCT) comparing a 1-year extension of early intervention (Ex...

journal_title：Schizophrenia research

authors： Chang WC,Kwong VW,Chan GH,Jim OT,Lau ES,Hui CL,Chan SK,Lee EH,Chen EY

更新日期：2016-05-01 00:00:00

abstract：:Childhood trauma is a risk factor for the onset of schizophrenic psychosis. Because the psychosis phenotype can be described as a continuum with varying levels of severity and persistence, childhood trauma might likewise increase the risk for psychotic experiences below the diagnostic threshold. But the impact of stre...

journal_title：Schizophrenia research

authors： Rössler W,Ajdacic-Gross V,Rodgers S,Haker H,Müller M

更新日期：2016-04-01 00:00:00

abstract：UNLABELLED:Subjective quality of life (S-QoL) is an important outcome measure in first episode psychosis (FEP). The aims of this study were to describe S-QoL-development the first 10-years in FEP patients and to identify predictors of this development. METHODS:A representative sample of 272 patients with a first episo...

journal_title：Schizophrenia research

authors： Gardsjord ES,Romm KL,Friis S,Barder HE,Evensen J,Haahr U,ten Velden Hegelstad W,Joa I,Johannessen JO,Langeveld J,Larsen TK,Opjordsmoen S,Rund BR,Simonsen E,Vaglum P,McGlashan T,Melle I,Røssberg JI

更新日期：2016-04-01 00:00:00

abstract：:Mental illness stigma may contribute to suicidality and is associated with social isolation and low self-esteem among young people at risk of psychosis. However, it is unclear whether mental illness stigma contributes to suicidality in this population. We therefore examined the associations of self-labeling and stigma...

journal_title：Schizophrenia research

authors： Xu Z,Müller M,Heekeren K,Theodoridou A,Metzler S,Dvorsky D,Oexle N,Walitza S,Rössler W,Rüsch N

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Structural pathology in the hippocampus is well-documented in schizophrenia, but brain functional changes have not been consistently found. We used spatial navigation in a virtual reality environment, a task that is known to produce robust hippocampal activation in healthy subjects, to examine task-related a...

journal_title：Schizophrenia research

authors： Salgado-Pineda P,Landin-Romero R,Portillo F,Bosque C,Pomes A,Spanlang B,Franquelo JC,Teixido C,Sarró S,Salvador R,Slater M,Pomarol-Clotet E,McKenna PJ

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Schizophrenia is a disabling complex mental disorder and despite all available treatment, many patients unfortunately remain partial- or non-responders. A large body of research has shown that oxytocin is an important prosocial peptide and there is initial evidence that the central oxytocin system is altered...

journal_title：Schizophrenia research

authors： Dagani J,Sisti D,Abelli M,Di Paolo L,Pini S,Raimondi S,Rocchi MB,Saviotti FM,Scocco P,Totaro S,Balestrieri M,de Girolamo G

更新日期：2016-04-01 00:00:00

abstract：:The extent of age-related changes in glutamate and other neurometabolites in the anterior cingulate cortex (ACC) in individuals with schizophrenia remain unclear. Magnetic resonance spectroscopy (MRS) at 7 T, which yields precise measurements of various metabolites and can distinguish glutamate from glutamine, was use...

journal_title：Schizophrenia research

authors： Brandt AS,Unschuld PG,Pradhan S,Lim IA,Churchill G,Harris AD,Hua J,Barker PB,Ross CA,van Zijl PC,Edden RA,Margolis RL

更新日期：2016-04-01 00:00:00

abstract：:Recent research conducted in high-income countries suggests psychotic experiences are common in the general population, but evidence from low- and middle-income countries (LMIC) remains limited. Sri Lanka is a LMIC affected by three decades of civil conflict and, in 2004, a devastating tsunami. This study aimed to inv...

journal_title：Schizophrenia research

authors： Keraite A,Sumathipala A,Siriwardhana C,Morgan C,Reininghaus U

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Several resting-state neuroimaging studies in schizophrenia indicate an excessive brain activity while others report an incoherent brain activity at rest. No direct evidence for the simultaneous presence of both excessive and incoherent brain activity has been established to date. Moreover, it is unclear whe...

journal_title：Schizophrenia research

authors： Liu C,Xue Z,Palaniyappan L,Zhou L,Liu H,Qi C,Wu G,Mwansisya TE,Tao H,Chen X,Huang X,Liu Z,Pu W

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Although altered gamma-aminobutyric acid (GABA) neurotransmission has been implicated in the pathophysiology of schizophrenia, it is unclear whether the influence of GABA on working memory processes is confounded by nicotine use in this population. It is therefore crucial to evaluate working memory and its u...

journal_title：Schizophrenia research

authors： Bridgman AC,Barr MS,Goodman MS,Chen R,Rajji TK,Daskalakis ZJ,George TP

更新日期：2016-03-01 00:00:00

abstract：:By employing a novel semi-parametric extrapolation method, the life expectancies after the first hospitalization for schizophrenia and the associated lifetime healthcare expenditures were both estimated. Based on the linkage between the National Health Insurance Research Database and the National Mortality Registry of...

journal_title：Schizophrenia research

authors： Lêng CH,Chou MH,Lin SH,Yang YK,Wang JD

更新日期：2016-03-01 00:00:00

abstract：:Social perception and mentalizing are fundamental social cognitive abilities that are related to functioning and are impaired in schizophrenia. A novel approach to examine the relationship between social cognition and community functioning is to first functionally categorize individuals with schizophrenia and then eva...

journal_title：Schizophrenia research

authors： Karpouzian TM,Alden EC,Reilly JL,Smith MJ

更新日期：2016-03-01 00:00:00

abstract：:Past studies have demonstrated that the Brief Negative Symptom Scale (BNSS) has excellent psychometric properties in patients with schizophrenia. In the current study, we extended this literature by examining psychometric properties of the BNSS in outpatients diagnosed with bipolar disorder (n=46), outpatients with sc...

journal_title：Schizophrenia research

authors： Strauss GP,Vertinski M,Vogel SJ,Ringdahl EN,Allen DN

更新日期：2016-02-01 00:00:00

abstract：:Despite robust evidence of neurocognitive dysfunction in psychotic patients, the degree of similarity in cognitive architecture across psychotic disorders and among their respective first-degree relatives is not well delineated. The present study examined the latent factor structure of the Brief Assessment of Cognitio...

journal_title：Schizophrenia research

authors： Hochberger WC,Hill SK,Nelson CL,Reilly JL,Keefe RS,Pearlson GD,Keshavan MS,Tamminga CA,Clementz BA,Sweeney JA

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Prospective memory (PM) deficits have been consistently found in people with schizophrenia. Although there is evidence to suggest that PM deficits may be putative markers for schizophrenia, no longitudinal study has investigated the persistence of PM deficits. AIMS:We examined whether PM deficits persist af...

journal_title：Schizophrenia research

authors： Cheung EFC,Lui SSY,Wang Y,Yang TX,Shum DHK,Chan RCK

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Since the early description of paranoia, the nosology of delusional disorder has always been controversial. The old idea of unitary psychosis has now gained some renewed value from the dimensional continuum model of psychotic symptoms. AIMS:1. To study the psychopathological dimensions of the psychosis sp...

journal_title：Schizophrenia research

authors： Muñoz-Negro JE,Ibanez-Casas I,de Portugal E,Ochoa S,Dolz M,Haro JM,Ruiz-Veguilla M,de Dios Luna Del Castillo J,Cervilla JA

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:The Recovery Assessment Scale (RAS) is one of the most widely used measurements of recovery in mental health research. To date, no data have been available concerning the psychometric characteristics of the RAS in homeless people with severe mental illness. The aim of this study was to provide new data regard...

journal_title：Schizophrenia research

authors： Girard V,Tinland A,Mohamed EH,French Housing First Study Group.,Boyer L,Auquier P

更新日期：2015-12-01 00:00:00

abstract：:Accumulating evidence showed that interleukin-2 (IL-2) may be involved in the pathophysiology of schizophrenia. Increased IL-2 levels have been found in the serum of schizophrenia patients with mixed results. In the present study, we assessed serum IL-2 levels in a large group of 160 schizophrenia patients compared to...

journal_title：Schizophrenia research

authors： Tan Y,Li Y,Tan S,Wang Z,Yang FD,Cao B,Zunta-Soares GB,Soares JC,Zhang XY

更新日期：2015-12-01 00:00:00